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Date Published: November 5, 2018

Author: Science Daily

Summary of Article’s Focus:

Researchers have identified a protein that determines the identity and invasive properties of breast cancer cells. The finding could lead to the development of new therapeutic and diagnostic strategies to target breast cancer invasion and metastasis.

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Relevance to Your Original Work:

For my expertise in the Akt signaling, I was asked to collaborate with a researcher from Karolinska Institute to investigate the interplay between Akt and CAR membrane protein. We have found that the CAR trans-membrane protein is an important anchoring point for breast cancer cells, preventing them from losing their epithelial cell identity and becoming invasive. We found that CAR regulates the stability and function of the phosphatases and AKT inhibitors PTEN and PHLPP2.

Which of your above projects does this coverage report on?

The article is related to the project: Akt signaling and coordinated changes in the distribution and expression of Akt-regulating phosphatases.

The published paper the article refers to:

Nilchian A, Johansson J, Ghalali A, Asanin ST, Santiago A, Rosencrantz O, Sollerbrant K, Vincent CT, Sund M, Stenius U, Fuxe J. CXADR-Mediated Formation of an AKT Inhibitory Signalosome at Tight Junctions Controls Epithelial-Mesenchymal Plasticity in Breast Cancer. Cancer Res. 2019 Jan 1;79(1):47-60.