Date Published: November 5th 2018
Author: Press Office, Karolinska Institutet
Summary of Article’s Focus:
Researchers from Karolinska Institutet in Sweden have identified a protein that determines the identity and invasive properties of breast cancer cells. The finding could lead to the development of new therapeutic and diagnostic strategies to target breast cancer invasion and metastasis.
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Relevance to Your Original Work:
For my expertise in the Akt signaling, I was asked to collaborate with a researcher from Karolinska Institutet to investigate the interplay between Akt and CAR membrane protein. We have found that the CAR trans-membrane protein is an important anchoring point for breast cancer cells, preventing them from losing their epithelial cell identity and becoming invasive. We found that CAR regulates the stability and function of the phosphatases and AKT inhibitors PTEN and PHLPP2.
The published paper the article refers to:
Nilchian A, Johansson J, Ghalali A, Asanin ST, Santiago A, Rosencrantz O, Sollerbrant K, Vincent CT, Sund M, Stenius U, Fuxe J. CXADR-Mediated Formation of an AKT Inhibitory Signalosome at Tight Junctions Controls Epithelial-Mesenchymal Plasticity in Breast Cancer. Cancer Res. 2019 Jan 1;79(1):47-60.